Chemiluminescencross linked C-telopeptide of type I collagen (CTX) for Automatic immunoassay analyzer in Bone Metabolism

Chemiluminescencross linked C-telopeptide of type I collagen (CTX) for Automatic immunoassay analyzer in Bone Metabolism

<sup>Used in in vitro diagnostics as an indicator of bone resorption in humans and contributes to
A. Monitor changes in bone resorption under the following conditions
1. Anti-resorptive therapy in postmenopausal women
2. Hormone replacement therapy (HRT) with hormones and hormone-like drugs
3. Bisphosphonate therapy 2) Anti-resorptive therapy for individuals diagnosed with osteopenia</sup>

^{B. Predicting bone mineral density (BMD) response in postmenopausal women receiving antiresorptive therapy}

^{1. Hormone replacement therapy (HRT) with hormones and hormone-like drugs 2. Bisphosphonate therapy}

^{3. To a certain extent, it reflects the patient's disease activity and bone destruction.}

^{4. As a sensitive bone metabolism index, CTX-1 has a certain reference value in predicting the occurrence of KOA and evaluating the therapeutic effect of knee osteoarthritis.}

^{Application department of serum type I collagen C-terminal peptide kit:}

^{Orthopedics / Endocrinology / Rheumatology / Physical Examination / Gynecology}

Type I collagen is the most abundant form of collagen in the human body and is the only collagen component in bone, accounting for more than 90% of bone matrix.
During the continuous remodeling of the bone matrix throughout the skeleton, type I collagen is degraded, the lower fragments are released into the blood, and some appear in the urine. Determination of the content and changes of these small fragments in blood and urine can evaluate the state of bone resorption, which is not only helpful for the diagnosis of metabolic bone disease, but also can monitor and evaluate the efficacy of anti-bone resorption drugs.
Collagen type I C-terminal peptide (CTX), one of these small peptide fragments. The complete C-terminal peptide of type I collagen contains 26 amino acids, and the 15th to 22nd amino acids are in turn gluten-lys-propane=group-aspart-gly-glyc-arginine (EKAHDGGR). The C-terminus of the collagen α1(I) chain is specific and is called the 8 amino acid sequence (8AA). CTX is only derived from mature collagen fibers, not from newly synthesized collagen; it is neither degraded nor reused in the body, which can directly reflect the degradation of collagen fibers; collagen diet has no effect on it; it is more specific and reflects bone Smaller changes in collagen turnover are more sensitive.
The clinical application of CTX is mainly to determine the state of bone resorption in metabolic bone disease, and to detect and evaluate the efficacy of anti-bone resorption drugs.

Chemiluminescencross linked C-telopeptide of type I collagen (CTX) for Automatic immunoassay analyzer in Bone Metabolism Images